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. 2020 Apr 16;9(4):324. doi: 10.3390/antiox9040324

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Glioprotective effects of Mn-TM-2-PyP and resveratrol against reactive astrocytosis- and tBHP-induced oxidative stress. (A) Pretreatment of optic nerve head astrocytes with Mn-TM-2-PyP resulted in complete protection against both reactive astrocytosis- and tBHP-induced oxidative stress, as determined by MTT assay. (B) Similarly, lactate dehydrogenase (LDH) assay revealed potent glioprotection by Mn-TM-2-PyP. (C) Resveratrol exerted strong glioprotective effects that resulted in a statistically significant shift in the IC₅₀ value for tBHP. (D) Similar shifts were observed in the tBHP dose-response curve in the LDH assay. Data are shown as mean ± s.e.m. from three (Mn-TM-2-PyP) or four (resveratrol) separate experiments, with eight technical replicates per experiment.