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Trolox and xanthohumol are glioprotective against reactive astrocytosis- and chemically induced oxidative stress. (n.d. = not determined).
| Antioxidant | Condition | Control | Reactive Astrocytosis | ||
|---|---|---|---|---|---|
| MTT IC50 (tBHP) |
LDH EC50 (tBHP) |
MTT IC50 (tBHP) |
LDH EC50 (tBHP) |
||
| Trolox | Vehicle (0.1% ethanol) | 73.0 | 126.7 | 50.0 | 93.1 |
| Trolox (100 µM) | 135.2 | n.d. | 99.3 | 210.3 | |
| Xanthohumol | Vehicle (0.01% DMSO) | 143.2 | 185.4 | 94.4 | 113.0 |
| Xanthohumol (2.5 µM) | 159.1 | 210.9 | 108.9 | 145.9 | |
