Table 2.
Clinical characteristics of patients stratified by tranexamic acid administration. Continuous variables expressed as mean ± standard deviation
| Total (n = 71) | TXA (n = 14) | No TXA (n = 57) | P-value | |
|---|---|---|---|---|
| Age, y | 25.2 ± 4.9 | 24.2 ± 3.1 | 25.5 ± 5.3 | 0.64 |
| ISS | 28.2 ± 12.3 | 36.6 ± 12.5 | 26.2 ± 11.4 | 0.003* |
| Penetrating TBI, n | 36 (50.7%) | 6 (42.3%) | 30 (52.6%) | 0.56 |
| Blast injury, n | 57 (80.3%) | 12 (85.7%) | 45 (80.0%) | 0.72 |
| Gunshot wound, n | 13 (18.3%) | 2 (14.3%) | 11 (19.3%) | 0.72 |
| Received massive transfusion within 24 h, n | 9 (12.7%) | 4 (28.6%) | 5 (8.8%) | 0.07 |
| Platelets < 100 (×109/L), n | 7 (9.9%) | 3 (21.4%) | 4 (7.0%) | 0.13 |
| INR > 1.5, n | 14 (19.7%) | 7 (50.0%) | 7 (12.3%) | 0.004* |
| Lower extremity amputation, n | 6 (8.5%) | 5 (35.7%) | 1 (1.8%) | < 0.001* |
| Pelvic fracture, n | 3 (4.2%) | 1 (7.1%) | 2 (3.5%) | 0.5 |
| Chest AIS 3+, n | 17 (23.9%) | 6 (42.3%) | 11 (19.3%) | 0.2 |
| Abdomen AIS 3+, n | 8 (11.3%) | 3 (21.4%) | 5 (8.8%) | 0.19 |
| Extremity AIS 3+, n | 19 (26.8%) | 8 (57.1%) | 11 (19.3%) | 0.008* |
| Type of ICH | ||||
| Epidural, n | 8 (11.3%) | 3 (21.4%) | 5 (8.8%) | 0.19 |
| Subdural, n | 33 (46.5%) | 6 (42.3%) | 27 (47.4%) | 1.00 |
| Intraparenchymal, n | 57 (80.3%) | 14 (100%) | 43 (75.4%) | 0.06 |
| Subarachnoid, n | 43 (60.6%) | 8 (57.1%) | 35 (61.4%) | 0.77 |
| Intraventricular, n | 18 (25.3%) | 6 (42.9%) | 12 (21.1%) | 0.17 |
| Presence of DAI, n | 7 (9.9%) | 2 (14.3%) | 5 (8.8%) | 0.62 |