Table 4.
The comparisons of CSF laboratory examinations across mNGS subgroups
| mNGS positive/Case consistent (a) | mNGS positive/Case inconsistent (b) | mNGS negative/Case inconsistent (c) | mNGS negative/Case consistent (d) | p value among all groups (Mann–Whitney test) | p value between group a and c (Mann–Whitney test) | p value between group a and d (Mann–Whitney test) | |
|---|---|---|---|---|---|---|---|
| Suspected CNS infections (a = 61; b = 7; c = 98; d = 70) | |||||||
| CSF WBC,*106/L (Median(Range)) | 130 (1–26,000) | 60 (1–110) | 68 (1–1630) | 7 (0–340) | 0.001* | 0.002* | < 0.0001* |
| CSF protein, mg/L (Median(Range)) | 1741.0 (209.0–15,000.0) | 839.5 (208.0–5477.0) | 1351.0 (33.0–15,000.0) | 686.0 (208.0–13,223.0) | 0.065 | 0.002* | < 0.0001* |
| CSF/serum glucose ratio (Mean (Range)) | 0.36 (0.06–0.71) | 0.37 (0.24–0.5) | 0.42 (0.10–0.75) | 0.60 (0.13–1.19) | 0.023* | 0.003* | < 0.0001* |
| CSF Cl, mmol/L (Mean(Range)) | 115.65 (97.00–143.00) | 119.50 (104.00–130.00) | 116.81 (92.00–130.00) | 118.52 (96.00–132.00) | 0.845 | 0.110 | 0.29 |
| CSF pressure, mmH2O (Mean(Range)) | 198.16 (50.00–300.00) | 159.40 (70.00–300.00) | 194.19 (88.00–300.00) | 185.47 (80.00–300.00) | 0.598 | 0.794 | 0.24 |
| Bacteria (a = 43; b = 5; c = 56; d = 126) | |||||||
| CSF WBC, *106/L (Median(Range)) | 138 (1–26,000) | 40 (1–110) | 68 (4–1630) | 20 (0–730) | 0.000 * | 0.029* | < 0.0001* |
| CSF protein, mg/L (Median (Range)) | 1845.5 (209.0–14,224.0) | 1112.0 (208.0–2499.0) | 1100.0 (33.0–15,000.0) | 867.0 (208.0–15,000.0) | 0.118 | 0.115 | 0.000* |
| CSF/serum glucose ratio (Mean(Range)) | 0.29 (0.06–0.52) | 0.42 (0.31–0.55) | 0.41 (0.19–0.75) | 0.53 (0.10–1.19) | 0.085 | 0.001* | < 0.0001* |
| CSF Cl, mmol/L (Mean(Range)) | 115.32 (98.00–131.00) | 117.20 (104.00–122.00) | 114.96 (92.00–126.00) | 118.49 (96.00–143.00) | 0.680 | 0.677 | 0.076 |
| CSF pressure, mmH2O (Mean(Range)) | 212.68 (92.00–300.00) | 135.00 (70.00–215.00) | 192.48 (88.00–300.00) | 188.01 (50.00–300.00) | 0.153 | 0.286 | 0.114 |
| Virus (a = 9; b = 2; c = 32; d = 187) | |||||||
| CSF WBC,*106/L (Median(Range)) | 161 (45–300) | 121 (2–242) | 35 (1–570) | 46 (0–26000) | 0.724 | 0.019* | 0.116 |
| CSF protein, mg/L (Median(Range)) | 1657.0 (662.0–6459.0) | 1036.5 (671.0–1456.0) | 937.5 (208.0–6741.0) | 1066.0 (33.0–15,000.0) | 0.190 | 0.012 | 0.125 |
| CSF/serum glucose ratio (Mean(Range)) | 0.44 (0.36–0.59) | 0.50 (0.39–0.62) | 0.48 (0.31–0.73) | 0.45 (0.06–1.19) | 0.994 | 0.299 | 0.539 |
| CSF Cl, mmol/L (Mean(Range)) | 117.57 (100.00–131.00) | 123.50 (113.00–134.00) | 119.61 (104.00–143.00) | 116.49 (92.00–132.00) | 0.785 | 0.579 | 0.527 |
| CSF pressure, mmH2O (Mean(Range)) | 194.17 (100.00–230.00) | 140.00 (85.00–195.00) | 191.35 (100.00–300.00) | 192.28 (50.00–300.00) | 0.772 | 0.935 | 0.812 |
| Fungi (a = 8; b = 0; c = 3; d = 219) | |||||||
| CSF WBC, *106/L (Median(Range)) | 115 (70–730) | N/A | 2 (2–15) | 44 (0–26,000) | 0.902 | 0.238 | < 0.0001* |
| CSF protein, mg/L (Median (Range)) | 1122.5 (520.0–15,000.0) | 1480.0 (1401.0–1484.0) | 1060.0 (33.0–7098.0) | 0.145 | 0.548 | 0.377 | |
| CSF/serum glucose ratio (Mean(Range)) | 0.33 (0.16–0.52) | 0.40 (0.24–0.52) | 0.46 (0.06–1.19) | 0.774 | 0.548 | 0.093 | |
| CSF Cl, mmol/L (Mean(Range)) | 111.83 (97.00–122.00) | 122.33 (116.00–130.00) | 117.18 (92.00–143.00) | 0.684 | 0.381 | 0.461 | |
| CSF pressure, mmH2O (Mean(Range)) | 170.00 (50.00–300.00) | 146.67 (130.00–160.00) | 193.15 (70.00–300.00) | 0.403 | 0.786 | 0.611 | |
| Parasite (a = 2; b = 0; c = 1; d = 227) | |||||||
| CSF WBC, *106/L (Median(Range)) | 34 (9–58) | N/A | 0 (N/A) | 50 (0–26,000) | 0.947 | N/A | 0.686 |
| CSF protein, mg/L (Median(Range)) | 959.0 (506.0–1412.0) | 181.0 (N/A) | 1079.5 (33.0–15,000.0) | 0.682 | 0.706 | ||
| CSF/serum glucose ratio (Mean(Range)) | 0.36 (0.29–0.42) | 0.65 (N/A) | 0.46 (0.06–1.19) | 0.879 | 0.458 | ||
| CSF Cl, mmol/L (Mean(Range)) | 119.50 (111.00–128.00) | 127.00 (N/A) | 117.04 (92.00–143.00) | 0.843 | 0.703 | ||
| CSF pressure, mmH2O (Mean(Range)) | 222.50 (150.00–295.00) | 135.00 (N/A) | 191.13 (50.00–300.00) | 0.588 | 0.697 | ||
Statistics analysis: Mann–Whitney test as listed in Table 4
*p value < 0.05