Table 3.
Analgesic activity of arachic acid ethyl ester (AAEE) induced by the hot plate method in rats.
| Treatment | Time (hour) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 0 | 0.5 | 1 | 2 | 3 | 4 | 5 | 6 | ||
| Palm oil (mL/kg) | 10 | 6.8 ± 1.9 | 5.0 ± 1.0 | 6.2 ± 2.7 | 5.2 ± 1.1 | 5.4 ± 1.8 | 5.0 ± 1.7 | 5.0 ± 0.7 | 5.0 ± 0.7 |
| Morphine (mg/kg) | 2.5 | 5.8 ± 3.5 | 7.6 ± 4.0 (34) |
20.0 ± 5.9∗ (69) |
22.0 ± 7.2∗ (76) |
25.4±6.8∗∗ (79) |
25.2±5.7∗∗ (80) |
24.8 ± 7, 8∗∗ (80) |
20.8±7.3∗∗ (76) |
| AAEE (mg/kg) | 12.5 | 6.6 ± 2.1 | 10.6 ± 3.4∗ (53) |
12.2 ± 3.0 (49) |
11.2 ± 5.8 (54) |
13.6 ± 6.1 (60) |
13.2 ± 6.9 (62) |
7.4 ± 2.3 (32) |
7.2 ± 1.9 (31) |
| 25 | 6.8 ± 1.1 | 13.2 ± 3.7∗ (62) |
13.6 ± 3.0 (54) |
14.4 ± 3.7 (64) |
12.4 ± 3.2 (56) |
10.4 ± 2.9 (52) |
8.0 ± 3.2 (37) |
8.4 ± 1.9 (40) |
|
| 50 | 6.4 ± 1.7 | 7.0 ± 1.2 (29) |
20.2 ± 9.2∗ (69) |
26.0±6.8∗∗ (80) |
22.4 ± 7.0∗ (76) |
19.8 ± 6.8∗ (75) |
24.8±7.6∗∗ (80) |
25.8±7.8∗∗ (81) |
|
Each value is the mean of latency time (s) on the hot plate ± SEM (n = 5). Significant difference: ∗p < 0.05 and ∗∗p < 0.01 compared with control at the same time point. (): % of analgesic activity.