Table 1.
Comparisons of genotype distribution, allele frequency, and genetic models of rs16944, rs1143627, rs4251961, and rs1800796 between PTOM patients and healthy controls.
| SNP | Item | Patients | Controls | Test statistics | P values | OR (95% CI) | |
|---|---|---|---|---|---|---|---|
| rs16944 | Genotype (n, %) | AA | 30 (15.87) | 52 (26.0) | 6.012 | 0.049 | |
| AG | 98 (51.85) | 90 (45.0) | |||||
| GG | 61 (32.28) | 58 (29.0) | |||||
| Allele frequency | G vs. A | 220/158 | 206/194 | 3.523 | 0.061 | 1.311 (0.988-1.741) | |
| Dominant model | GG+AG vs. AA | 159/30 | 148/52 | 5.733 | 0.017 | 1.854 (1.118-3.073) | |
| Recessive model | GG vs. AA+AG | 61/128 | 58/142 | 0.555 | 0.456 | 1.180 (0.764-1.822) | |
| Homozygous model | GG vs. AA | 61/30 | 58/52 | 4.184 | 0.041 | 1.831 (1.026-3.267) | |
| Heterozygous model | AG vs. AA | 98/30 | 90/52 | 5.225 | 0.022 | 1.869 (1.093-3.194) | |
|
| |||||||
| rs1143627 | Genotype (n, %) | CC | 31 (16.40) | 51 (25.5) | 4.928 | 0.085 | |
| CT | 97 (51.32) | 94 (47.0) | |||||
| TT | 61 (32.28) | 55 (27.5) | |||||
| Allele frequency | T vs. C | 219/159 | 204/196 | 3.769 | 0.052 | 1.323 (0.997-1.756) | |
| Dominant model | TT+CT vs. CC | 158/31 | 149/51 | 4.615 | 0.032 | 1.735 (1.050-2.868) | |
| Recessive model | TT vs. CC + CT | 61/128 | 55/145 | 1.202 | 0.273 | 1.278 (0.824-1.981) | |
| Homozygous model | TT vs. CC | 61/31 | 55/51 | 4.229 | 0.040 | 1.839 (1.029-3.285) | |
| Heterozygous model | CT vs. CC | 97/31 | 94/51 | 3.606 | 0.058 | 1.675 (0.984-2.853) | |
|
| |||||||
| rs4251961 | Genotype (n, %) | TT | 167 (88.36) | 155 (77.5) | 8.967 | 0.007 | |
| CT | 19 (10.05) | 42 (21.0) | |||||
| CC | 3 (1.59) | 3 (1.5) | |||||
| Allele frequency | C vs. T | 25/353 | 48/352 | 6.631 | 0.010 | 0.519 (0.313-0.861) | |
| Dominant model | CC+CT vs. TT | 22/167 | 45/155 | 7.980 | 0.005 | 0.446 (0.254-0.781) | |
| Recessive model | CC vs. TT+CT | 3/186 | 3/197 | 0.038 | 0.845 | 1.177 (0.231-6.007) | |
| Homozygous model | CC vs. TT | 3/167 | 3/155 | 0.000 | 0.985 | 1.016 (0.198-5.214) | |
| Heterozygous model | CT vs. TT | 19/167 | 42/155 | 8.844 | 0.003 | 0.409 (0.227-0.737) | |
|
| |||||||
| rs1800796 | Genotype (n, %) | GG | 3 (1.59) | 12 (6.0) | |||
| CG | 58 (30.69) | 64 (32.0) | 5.452 | 0.065 | |||
| CC | 128 (67.72) | 124 (62.0) | |||||
| Allele frequency | C vs. G | 314/64 | 312/88 | 3.176 | 0.075 | 1.384 (0.967-1.980) | |
| Dominant model | CC+CG vs. GG | 186/3 | 188/12 | 4.745 | 0.029 | 4.184 (1.154-15.165) | |
| Recessive model | CC vs. GG+CG | 128/61 | 124/76 | 1.433 | 0.231 | 1.295 (0.848-1.979) | |
| Homozygous model | CC vs. GG | 128/3 | 124/12 | 4.983 | 0.026 | 4.378 (1.197-16.007) | |
| Heterozygous model | CG vs. GG | 58/3 | 64/12 | 3.984 | 0.046 | 3.834 (1.024-14.347) | |
PTOM: posttraumatic osteomyelitis; OR: odds ratio; CI: confidence interval.