Fig. 1.

High fat induced endothelial inflammation and miRNAs may be involved in this response. a, relative mRNA levels of NF-κB p65, MCP-1, ICAM-1 and IL-6 in rat aortas. b, relative protein levels of p-NF-κB p65 in rat aortas. c, relative mRNA levels of NF-κB p65, MCP-1, ICAM-1 and IL-6 in HAECs. d, relative protein levels of p-NF-κB p65 in HAECs. e, relative expression levels of miR-146a, miR-155 and miR-21 in rat aortas. f, relative mRNA levels of IRAK1, TRAF6 and NF-κB p65 in rat aortas. g, relative protein levels of IRAK1, TRAF6 and NF-κB p65 in rat aortas. h, relative expression levels of miR-146a, miR-155 and miR-21 in HAECs. i, relative mRNA levels of IRAK1, TRAF6 and NF-κB p65 in HAECs. j, relative protein levels of IRAK1, TRAF6 and NF-κB p65 in HAECs. Data are presented as mean ± SEM. ^*P < 0.05 versus NC or BSA group. ^**P < 0.01 versus NC or BSA group. n = 6–8 rats per group for animal study. n = 5 per group for HAECs study