Table 2.
Abnormal electrocardiographic features in dogs experimentally infected with T. cruzi and treated with the DNA vaccine at 3, 6, and 12 months postinfection (mpi).
| Group∗ | Suggested pathological conditions by EKG recordings [78, 79] | Affected dogs (dogs/n) at 3 mpi | Affected dogs (dogs/n) at 6 mpi | Affected dogs (dogs/n) at 12 mpi |
|---|---|---|---|---|
| Inf/SS mock-treated | AV block+infarction | 20% (1/5) | ||
| Ischemia | 20% (1/5) | |||
| MEAD to the left+LBBB+infarction+ventricle enlargement | 20% (1/5) | |||
| MEAD to the right+RBBB+infarction+ventricle enlargement | 60% (3/5) | |||
| Arrhythmia+MEAD to the left+ventricle enlargement | 20% (1/5) | |||
| Ischemia+MEAD to the right+ventricle enlargement | 60% (3/5) | |||
|
| ||||
| pBCSSP4 | AV block | 20% (1/5) | ||
| LBBB | 20% (1/5) | |||
| MEAD to the right+RBBB+infarction | 20% (1/5) | |||
| MEAD to the left+LBBB+AV block | 20% (1/5) | |||
| LBBB+infarction+ischemia | 40% (2/5) | 20% (1/5) | ||
| RBBB+ischemia | 40% (2/5) | |||
|
| ||||
| pBCSP | AV block | 20% (1/5) | ||
| Infarction | 20% (1/5) | |||
| Infarction+ischemia | 20% (1/5) | 20% (1/5) | ||
| Arrhythmia+AV block | 20% (1/5) | |||
|
| ||||
| Mixture | AV block+infarction+RBBB | 20% (1/5) | ||
| Ischemia | 20% (1/5) | 20% (1/5) | ||
| Arrhythmia+ischemia | 20% (1/5) | |||
| AV block+ischemia | 20% (1/5) | 20% (1/5) | ||
|
| ||||
| pBK-CMV | Arrhythmia+ischemia | 20% (1/5) | ||
| MEAD to the left+ventricle enlargement | 40% (2/5) | |||
| MEAD to the left+LBBB+infarction+ventricle enlargement | 20% (1/5) | |||
| Arrhythmia+MEAD to the right+ventricle enlargement+ischemia | 20% (1/5) | |||
| MEAD to the right+RBBB+ventricle enlargement+infarction+ischemia | 40% (2/5) | |||
| Ventricle enlargement | 20% (1/5) | |||
| Arrhythmia+MEAD to the left+ventricle enlargement | 20% (1/5) | |||
| Arrhythmia+ventricle enlargement+ischemia+MIMI | 20% (1/5) | |||
∗Group descriptions are shown in Table 1. mpi = months postinfection; Inf = infected; AV = atrioventricular; LBBB = left bundle branch block; RBBB = right bundle branch block; MEAD = mean electrical axis deviation; MIMI = microscopic intramural myocardial infarction.