Table 1.

GO biological process enrichment analysis of DEGs.^16,17

	Term	P-value	Genes
Upregulated	GO:0002764–immune response-regulating signaling pathway	0.017683	PELI1, MEF2A, IRS2, LAMTOR3, F2RL1, RASGEF1A, IGKV4-1, ANGPT1, RAPGEF2, FCRL5
	GO:0042330–taxis	0.031543	ALCAM, NOV, IRS2, LAMTOR3, ST8SIA4, F2RL1, RASGEF1A, ANGPT1, RAPGEF2, EPHB1, SPP1
	GO:0006935–chemotaxis	0.031543	ALCAM, NOV, IRS2, LAMTOR3, ST8SIA4, F2RL1, RASGEF1A, ANGPT1, RAPGEF2, EPHB1, SPP1
	GO:0038095–Fc-epsilon receptor signaling pathway	0.040044	IRS2, LAMTOR3, RASGEF1A, IGKV4-1, ANGPT1, RAPGEF2
	GO:0034141–positive regulation of toll-like receptor 3 signaling pathway	0.04084	PELI1, F2RL1
	GO:0050776–regulation of immune response	0.041524	PELI1, MEF2A, IRS2, LAMTOR3, HLX, F2RL1, RASGEF1A, IGKV4-1, ANGPT1, RAPGEF2, FCRL5, IFNGR1
Downregulated	GO:0002437–inflammatory response to antigenic stimulus	0.001872	ELANE, HLA-DRB4, SPN
	GO:0050728–negative regulation of inflammatory response	0.006285	ELANE, HLA-DRB4, SPN
	GO:0002862–negative regulation of inflammatory response to antigenic stimulus	0.012856	HLA-DRB4, SPN
	GO:0002438–acute inflammatory response to antigenic stimulus	0.022107	ELANE, SPN
	GO:0002684–positive regulation of immune system process	0.022618	PSMF1, ELANE, HLA-DRB4, TAB3, SPN
	GO:0002861–regulation of inflammatory response to antigenic stimulus	0.023258	HLA-DRB4, SPN
	GO:0050776–regulation of immune response	0.029438	PSMF1, ELANE, HLA-DRB4, TAB3, SPN
	GO:0006955–immune response	0.041101	APOBEC3B, PSMF1, ELANE, HLA-DRB4, TAB3, SPN
	GO:0050778–positive regulation of immune response	0.043136	PSMF1, ELANE, HLA-DRB4, TAB3
	GO:0050727–regulation of inflammatory response	0.045142	ELANE, HLA-DRB4, SPN

GO, Gene Ontology; DEG, differentially expressed gene.