Table 2.

Secondary endpoints

Endpoint	Time frame	Detailed description
Hypoxaemia	3 days	PaO2/FiO2 < 300 mmHg
Circulatory failure	28 days	Hypotension—MAP < 65 mmHg Severe cardiac arrhythmia—40/min < HR > 150/min ScvO2 < 70% dCO2 > 7 mmHg Serum lactate > 2 mmol/L Severe metabolic acidosis (actual bicarbonate < 18 mmol/L) Acute coronary syndrome Acute left ventricular failure Pulmonary embolism Cardiac arrest
Gastrointestinal dysfunction	28 days	Constipation Ileus Anastomotic leakage Reoperation Disorders of liver function
Renal dysfunction	28 days	RIFLE criteria
Hematologic and coagulation disorders	28 days	Severe bleeding Coagulopathy—INR > 1.5
Infection	28 days	Any infection except from pneumonia

PaO₂/FiO₂ ratio of arterial oxygen partial pressure to fraction of inspired oxygen; MAP mean arterial pressure; HR heart rate; ScvO₂ central venous oxygen saturation; dCO₂ arterial to central venous carbon dioxide difference; INR international normalized ratio