Table 6.
Postoperative results on POD1 to POD3
| POD1 | POD2 | POD3 | Composite results | P value | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| CG (n = 15) | SG (n = 15) | CG (n = 15) | SG (n = 15) | CG (n = 15) | SG (n = 15) | CG (n = 15) | SG (n = 15) | OR (95% CI) | ||
| Oxygenation | ||||||||||
| PaO2/FiO2 (mmHg) | 277.75 (72.79) | 299.85 (79.61) | 279.77 (81.43) | 270.02 (70.63) | 310.31 (87.98) | 311.83 (70.10) | 298.67 (44.68) | 307.60 (48.22) | 0.63 (0.25–1.63) | 0.342 |
| Haemodynamic data | ||||||||||
| MAP (mmHg) | 80.27 (14.06) | 79.97 (15.14) | 88.50 (13.84) | 83.07 (16.79) | 89.67 (10.57) | 84.13 (14.45) | 75.20 (10.97) | 72.39 (11.74) | 1.19 (0.52–2.73) | 0.673 |
| HR (min−1) | 84.13 (15.83) | 82.07 (18.91) | 80.00 (21.0) | 83.50 (20.0) | 80.67 (10.39) | 81.97 (14.24) | 82.23 (9.21) | 82.82 (11.57) | 1.12 (0.44–2.90) | 0.809 |
| ScvO2 (%) | 71.54 (7.56) | 70.67 (7.72) | 70.45 (5.89) | 70,78 (5.73) | 71.31 (6.11) | 70.49 (6.89) | 71.64 (4.47) | 70.94 (5.15) | 0.89 (0.36–2.25) | 0.814 |
| dCO2 (mmHg) | 6.58 (2.92) | 7.04 (2.58) | 6.68 (2.75) | 6.02 (2.41) | 6.25 (2.06) | 5.73 (1.96) | 5.96 (2.59) | 5.76 (2.38) | 0.43 (0.17–1.08) | 0.072 |
| Lactate (mmol l−1) | 1.28 (0.45) | 1.58 (0.74) | 1.09 (0.38) | 1.25 (0.65) | 1.22 (0.48) | 1.02 (0.33) | 1.20 (0.44) | 1.28 (0.63) | 3.72 (1.09–12.64) | 0.057 |
| pH | 7.43 (0.04) | 7.42 (0.05) | 7.43 (0.03) | 7.44 (0.05) | 7.42 (0.02) | 7.43 (0.03) | 7.43 (0.03) | 7.43 (0.04) | 0.33 (0.01–8.22) | 0.496 |
| stHCO3− (mmol l−1) | 25.19 (2.17) | 24.48 (2.77) | 25.14 (2.56) | 25.84 (2.72) | 24.71 (2.45) | 25.07 (1.88) | 25.02 (2.38) | 25.13 (2.53) | 1.05 (0.47–2.95) | 0.705 |
| IAP (mmHg) | 12.99 (6.19) | 11.69 (5.63) | 13.86 (7.93) | 12.08 (5.12) | 12.16 (6.68) | 11.75 (3.97) | 13.03 (6.92) | 11.84 (4.92) | 0.45 (0.23–0.87) | 0.062 |
| Fluid management | ||||||||||
| Crystalloids (ml) | 3000 [2500–3587] | 3000 [2700–3000] | 2700 [2000–3262] | 2500 [1650–3325] | 2500 [1500–2975] | 1600 [1500–2075] | 2800 [2000–3187] | 2300 [1600–3000] | 0.314 | |
| Colloids (ml) | 200 [0–200] | 400 [300–450] | 0 [0–0] | 0 [0–100] | 0 [0–0] | 0 [0–0] | 0 [0–0] | 0 [0–25] | 0.083 | |
| Oral intake (ml) | 1200 [1100–1925] | 800 [525–1100] | 1300 [1050–2000] | 1400 [875–1738] | 2000 [1325–2425] | 1500 [1225–2000] | 1400 [1100–2000] | 1230 [750–1850] | 0.089 | |
| Urine output (ml) | 3050 [2125–4150] | 2460 [2125–2900] | 3800 [2745–4538] | 2800 [2713–3425] | 3700 [3050–4185] | 2600 [2150–3175] | 3600 [2835–4300] | 2750 [2275–3212] | 0.001 | |
| Blood loss (ml) | 50 [0–200] | 100 [0–200] | 0 [0–0] | 0 [0–0] | 0 [0–0] | 0[0–0] | 0 [0–0] | 0 [0–12.5] | 0.685 | |
| Fluid balance (ml) | 800 [490–2185] | 1700 [660–1890] | 200 [-640 to 1580] | 830 [-62 to 2125] | 300 [-12 to 950] | 800 [-25 to 1575] | 460 [-100 to 1532] | 1200 [162–1938] | 0.114 | |
| PRBC units transfused | ||||||||||
| 0 U | 9 (60) | 9 (60) | 10 (67) | 10 (67) | 15 (100) | 11 (73) | 34 (76) | 30 (67) | 1.55 (0.62–3.88) | 0.354 |
| 1–3 U | 6 (40) | 6 (40) | 4 (27) | 5 (33) | 0 | 4 (27) | 10 (22) | 15 (33) | 0.57 (0.22–1.46) | 0.242 |
| > 3 U | 0 | 0 | 1 (6) | 0 | 0 | 0 | 1 (2) | 0 (0) | 0.33 (0.01–8.22) | 0.496 |
| Laboratory results | ||||||||||
| Platelet count (G l−1) | 197 (57.57) | 191 (40.92) | 183 (56.47) | 163 (38.47) | 186 (63.93) | 162 (45.99) | 189 (58.41) | 172 (42.97) | 1.12 (0.52–3.25) | 0.814 |
| Bilirubin (μmol l−1) | 10.4 (3.09) | 16.6 (13.08) | 7.9 (2.36) | 12.3 (9.90) | 8.5 (2.33) | 10.7 (6.54) | 8.9 (2.77) | 13.2 (10.28) | 5.50 (0.62–19.11) | 0.127 |
| Creatinine (μmol l−1) | 102 [83.50–132.75] | 131 [94.00–180.75] | 94 [80.00–123.75] | 136 [88.50–163.00] | 92.0 [79.25–128.50] | 124.0 [73.25–157.25] | 94 [80.00–128.25] | 131 [88.75–166.50] | 2.05 (0.89–4.75) | 0.022 |
| BUN (mmol l−1) | 4.9 [3.9–5.9] | 5.1 [4.3–8.8] | 4.4 [3.4–5.4] | 5.3 [3.5–7.6] | 4.8 [3.9–5.5] | 5.1 [4.5–7.9] | 4.6 [3.8–5.3] | 5.1 [4.3–7.9] | 3.25 (0.61–6.52) | 0.044 |
Data are expressed as number n (%), mean (SD) or median [IQR]
POD postoperative day; CG control group; SG study group; OR odds ratio; PaO2/FiO2 ratio of arterial oxygen partial pressure to fractional inspired oxygen; MAP mean arterial pressure; HR heart rate; ScvO2 central venous oxygen saturation; dCO2 arterial to central venous carbon dioxide difference; stHCO3− arterial standard bicarbonate; IAP intraabdominal pressure; PRBC packed red blood cells; U unit; BUN blood urea nitrogen; SD standard deviation; IQR interquartile range
Italics value indicates number of subjects or number of events