Table 2.
Examples of antibodies against α-synuclein in clinical development
| Antibody | Phase | Binding | Epitope | Isotype | Safety |
|---|---|---|---|---|---|
|
PRX002/RG7935 (Prothena/Roche) |
I-II |
Monomers ++ Oligomers +++ Fibrils + |
C-term aa 118-126 |
IgG1 | Well tolerated |
|
BIIB-054 (Biogen) |
I-II |
Monomers −/+ Oligomers +++ Fibrils +++ |
N-term aa 1-10 |
IgG1 | Well tolerated |
|
MEDI1341 (MedImmune/Astra Zeneca/Takeda) |
Preclinical |
Monomers + Oligomers +++ Fibrils ++ |
C-term aa 103-129 |
IgG1 | In progress |
|
ABBV-0805/BAN0805 (BioArtic/AbbVie) |
I |
Monomers 0 Oligomers ++ Fibrils +++ |
aa ? | IgG? | In progress |
|
Lu AF82422 (Lundbeck) |
I |
Monomers + Oligomers ++ Fibrils ++ |
C-term aa 112-117? |
IgG1 | In progress |