. 2020 Mar 5;59(8):1027–1036. doi: 10.1007/s40262-020-00873-3

Table 1.

Population pharmacokinetic model builds and comparisons

Models	Volume of distribution	Total elimination rate constant	-2LL	AIC	Change in OFV	Population			Bayesian
Models	Volume of distribution	Total elimination rate constant	-2LL	AIC	Change in OFV	Bias	Imprecision	R²	Bias	Imprecision	R²
Base 1-compt	V₀	K_e	3223	3229	–	0.82	21.3	0.23	− 0.05	1.66	0.847
Base 2-compt	V₀	K_e	2994	3004	229	1.91	41.9	0.28	0.70	3.87	0.852
2-compt	V₀ · (WT/70)	K_e · (WT/70)	2990	3000	4	2.17	68.4	0.61	− 0.18	1.12	0.965
Final 2-compt	V₀ · (WT/70)	[K_eIntcpt + (CrCL/120) · K_e0] · (WT/70)^− 0.25	2966	2978	34	0.53	7.75	0.87	− 0.15	1.07	0.965

− 2LL − 2 log-likelihood, AIC Akaike’s information criterion, OFV objective function value, WT weight in kg