Table 2.
Population pharmacokinetic parameter estimates from the final model
| Median (95% CI) | CV (%) | Shrinkage (%) | |
|---|---|---|---|
| V0 (L) | 11.172 (9.40, 12.50) | 22.66 | 14.7 |
| KeIntcpt (h−1) | 0.506 (0.33, 0.71) | 59.24 | 15.1 |
| Ke0 (h−1) | 0.236 (0.11, 0.40) | 133.95 | 6.8 |
| KCP (h−1) | 1.716 (1.02, 3.11) | 68.82 | 7.7 |
| KPC (h−1) | 1.502 (1.35, 1.90) | 60.63 | 8.8 |
V0 and KeIntcpt are standardized to weight (kg)/70 kg in the final structural model
Ke0 is standardized to weight (kg)/70 kg and creatinine clearance (mL/min)/120 mL/min in the final structural model
CI credibility interval, CV coefficient of variation