Fig. 5.

Schematic overview of the metabolites with serum levels significantly altered with thermal injury and P. aeruginosa sepsis. Metabolites with increased levels are in red and those with decreased levels are in blue; bold metabolites are included in the set of potential biomarkers for Pa-sepsis—25 of the 26 metabolites in the set map to these four interconnected pathways. Metabolites in purple were among the 148 identified metabolites detected in the sera but changes in their levels were not considered significant; however, they are intermediates in the pathways shown. Metabolites in black were not detected in our analysis. The rounded shapes labeled in all capitals contain the four metabolic pathways most interlinked. Solid lines, direct reactions; dotted lines, indirect reactions; arrowhead indicates direction of the reaction; double arrowhead, reversible reactions