Table 3.
Levels of AOPPs and 8-OHdG in relation to neonatal clinical characteristics among the RDS group
| Variables | Number (%) | AOPPs (ng/mL) Day 0 | P value | AOPPs (ng/mL) Day 3 | P value | 8-OHdG (pg/mL) Day 0 | P value | 8-OHdG (pg/mL) Day 3 | P value |
|---|---|---|---|---|---|---|---|---|---|
| Antenatal steroids intake | |||||||||
| Positive | 24 (60) | 80.6 ± 48.4 | 0.794 | 173.1 ± 57.8 | 0.003 | 2458.3 ± 1250.4 | 0.496 | 6000 ± 2595.9 | 0.529 |
| Negative | 16 (40) | 85.6 ± 48.9 | 230.9 ± 55.5 | 2718.8 ± 1048.3 | 6500 ± 2175.6 | ||||
| PROM | |||||||||
| Positive | 12 (30) | 80.14 ± 49.67 | 0.627 | 204.58 ± 72.35 | 0.591 | 2589.3 ± 1225.1 | 0.828 | 6089.3 ± 2490.9 | 0.664 |
| Negative | 28 (70) | 88.33 ± 45.39 | 192.68 ± 59.71 | 2500 ± 1066 | 6458.3 ± 2330.2 | ||||
| Sex | |||||||||
| Male | 25 (62.5) | 82.4 ± 49.3 | 0.968 | 192 ± 68.98 | 0.589 | 2420 ± 1057.5 | 0.325 | 6060 ± 2310.8 | 0.643 |
| Female | 15 (37.5) | 83 ± 47.4 | 203.3 ± 53.2 | 2800 ± 1333.6 | 6433.3 ± 2658.3 | ||||
| RDS radiological grade | |||||||||
| Grade II | 12 (30) | 40.8 ± 25.5 | <0.001 | 151.7 ± 50.7 | 0.002 | 1625 ± 644 | <0.001 | 4416.7 ± 1459 | 0.001 |
| Grade III and IV | 28 (70) | 100.5 ± 44.2 | 215.4 ± 58.6 | 2964.3 ± 1113.3 | 6964.3 ± 2360.7 | ||||
| Surfactant | |||||||||
| Positive | 26 (65) | 80.9 ± 49.2 | 0.861 | 230.6 ± 62.4 | 0.004 | 2468.8 ± 1056.2 | 0.684 | 5604.2 ± 2090.2 | 0.055 |
| Negative | 14 (35) | 83.7 ± 48.2 | 173.3 ± 53.2 | 2625 ± 1253.3 | 7093.8 ± 2665.9 | ||||
| IVH | |||||||||
| Positive | 8 (20) | 82.3 ± 46.3 | 0.97 | 213.1 ± 61.5 | 0.10 | 2881.8 ± 1728.1 | 0.347 | 6177.4 ± 2599.8 | 0.91 |
| Negative | 32 (80) | 82.8 ± 50.5 | 180.9 ± 61.8 | 2467.7 ± 965.5 | 6277.7 ± 1787.2 | ||||
| PDA | |||||||||
| Positive | 17 (42.5) | 78.5 ± 41.3 | 0.44 | 186.6 ± 57.1 | 0.61 | 2500 ± 1322.8 | 0.752 | 6473.6 ± 2573.7 | 0.50 |
| Negative | 23 (57.5) | 85.8 ± 51.8 | 199 ± 65.2 | 2619.1 ± 1035.6 | 5952.3 ± 2307.1 | ||||
| Mechanical ventilation | |||||||||
| Invasive | 26 (65) | 95 ± 42.4 | 0.024 | 219.2 ± 58.9 | 0.001 | 2942.3 ± 1098.4 | 0.004 | 6865.4 ± 2463.9 | 0.016 |
| Non-invasive | 14 (35) | 59.6 ± 3 0.7 | 153.6 ± 47.3 | 1857.1 ± 969.3 | 4964.3 ± 1834.1 | ||||
| Mortality | |||||||||
| Alive | 34 (85) | 75.9 ± 44.9 | 0.032 | 181.9 ± 55.3 | <0.001 | 2485.3 ± 1202.8 | 0.325 | 5676.5 ± 2018.4 | <0.001 |
| Died | 6 (15) | 120.8 ± 51.1 | 277.5 ± 38.9 | 3000 ± 894.4 | 9166.7 ± 2523.2 | ||||
Data were expressed as mean plus or minus SD, where Student’s t test was used for comparisons
RDS respiratory distress syndrome, AOPPs advanced oxidation protein products, 8-OHdG 8-hydroxy-desoxyguanosine, PROM premature rupture of membranes, IVH intraventricular hemorrhage, PDA patent ductus arteriosus, ANOVA analysis of variance