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. 2019 Nov 30;87(6):1025–1032. doi: 10.1038/s41390-019-0697-9

Table 3.

Neurological function, MRI findings, and neurodevelopmental outcomes.

Infant no. Thompson encephalopathy score aEEG pattern on admission Time to CNV (h of life) Seizure MRI findings Outcome (Bayley II at 18–22 months)
Pre During Post Age at MRI (days of life) Intracranial hemorrhage Diffusion abnormalities MDI PDI
1 11 DNV 4 No No No 2 SA ≥85 70–84
2 10 DNV 3 No No No 3 70–84 <70
3 11 FT 15 Susp. No No 3 SD WM, DGM ≥85 ≥85
4 13 FT No No Yes 4 WM, cortex, corpus callosum <70 <70
5 10 DNV 19 No No No 8 SD ≥85 ≥85
6 15 BS Yes Yes Yes 2 WM, DGM, corpus callosum Died
7 10 BS 37 Susp. No No 4 SA Corpus callosum Behavioral problems, total score of BRS: 88 (6 pc)
8 17 FT Susp. Yes Yes 5 SD, IVH grade I WM, DGM, corpus callosum <70 <70
9 7 DNV 4 No No No 3 ≥85 70–84
10 16 FT 62 No Yes Yes 7 SD WM, corpus callosum ≥85 ≥85

Bayley Scales of Infant Development II examination was performed at 18–22 months of age. The mental developmental index (MDI) and the psychomotor developmental index (PDI) are classified as moderate disability (<1 SD below the mean) if values are 70–84 and as severe disability if <70

aEEG amplitude-integrated electroencephalography, BRS behavioral rating scale, BS burst suppression, CNV continuous normal voltage, DGM deep gray matter, DNV discontinuous normal voltage, FT flat trace, Susp. clinically suspected seizure, not confirmed by aEEG, IVH intraventricular hemorrhage, MDI mental developmental index, MRI magnetic resonance imaging, PDI psychomotor developmental index, PVL periventricular leukomalacia, SA subarachnoid hemorrhage, SD subdural hemorrhage, WM white matter