Table 4.

Self-emulsifying drug delivery system (SEDDS)–based antimalarial formulations

Drug	Formulation	ROA	Comments	Reference
Artemether	Solid dispersions and self-emulsified solid dispersions	Oral	The solubility of artemether is enhanced.	[47]
β-Artemether	SMEDDS	Oral	The antimalarial activity was significantly enhanced (P < 0.05) as compared with the marketed formulation (Larither®).	[48]
β-Artemether and lumefantrine	SMEDDS	Oral	SMEDDS shows superior antimalarial activity with 100% survival as compared with the innovator (Coartem®) formulation.	[49]
Artemether-lumefantrine	Solid SMEDDS	Oral	Optimized SMEDDS formulation at a low, medium, and high doses found to be superior in terms of reduction in parasitemia as well as mortality in comparison with the marketed tablet of equivalent dose.	[50]