Table 4.

Cox proportional hazards survival analysis (model 6) for 3-year overall survival in women aged ≥50 years with ER-positive early invasive breast cancer in England between 2014 and 2017

	Total number of women	% women alive at 3 years	Adjusted OR	95% CI	P value
Age at diagnosis (years)	67 925	94	1.06	1.05 to 1.06	<0.001
Invasive grade
G1	13 352	96	1		<0.001
G2	40 999	94	1.05	0.96 to 1.16
G3	13 574	91	1.64	1.47 to 1.83
Tumour size (T stage)
1–20 mm (T0–1)	41 225	95	1		<0.001
21–50 mm (T2)	23 974	90	1.31	1.22 to 1.41
51+mm (T3)	2 726	89	1.69	1.48 to 1.93
Nodal metastasis (N-stage)
N0	49 837	94	1		<0.001
N1	15 594	93	1.39	1.29 to 1.50
N2	2 494	89	2.16	1.88 to 2.49
HER2 status
Positive	6 271	92	1		<0.001
Negative	56 564	94	0.81	0.73 to 0.90
Borderline	5 090	92	0.82	0.71 to 0.95
Deprivation status
1 (most deprived)	10 065	91	1		<0.001
2	12 131	93	0.86	0.78 to 0.95
3	14 137	94	0.74	0.67 to 0.82
4	15 998	94	0.77	0.70 to 0.85
5 (least deprived)	15 594	95	0.67	0.61 to 0.75
Charlson Comorbidity Index
0	58 488	96	1		<0.001
1	6 259	87	1.25	1.11 to 1.40
2	2 057	77	1.41	1.22 to 1.62
3+	1 121	59	1.86	1.59 to 2.18
Secondary care administrative records frailty index index
Fit	53 800	96	1		<0.001
Mild frailty	7 501	92	1.22	1.09 to 1.36
Moderate frailty	4 498	82	1.44	1.27 to 1.64
Severe frailty	2 126	61	1.63	1.41 to 1.89
Surgery
No	6 112	64	1		<0.001
Yes	61 813	96	0.21	0.20 to 0.23

*P value from z-test for continuous variables and Wald test for categorical variables.