Skip to main content

View full-text article in PMC

. 2020 Apr 8;10(4):919–944. doi: 10.1007/s13346-020-00733-4

Table 8.

Pharmacokinetic parameters of ATS-SLNs and ATS-SUS following topical administration (n = 4)

Formulation	Aqueous humor					Vitreous humor
Formulation	C_max (μg/ml)	T_max/T_1/2 (h)	AUC_0-t (h μg/ml)	MRT (h)	K_el (/h)	C_max (μg/ml)	T_max/T_1/2 (h)	AUC_0-t (h μg/ml)	MRT (h)	K_el (/h)
ATS-SLNs	1.11 ± 0.2	1.0/9.2	8.09 ± 0.3	13.3	0.075	1.43 ± 0.2	1.0/14.40	12.63 ± 0.3	20.7	0.048
ATS-SUS	0.71 ± 0.1	0.5/2.6	1.15 ± 0.2	3.8	0.260	0.47 ± 0.1	1.0/4.69	1..08 ± 0.1	6.7	0.147

All values observed for ATS-SLNs were significantly higher than those for ATS-SUS, at p < 0.05