Early extubation to non-invasive ventilation (NIV) did not shorten time to liberation from ventilation.

However, the probability of NIV being cost effective relative to weaning without NIV was modest: between 57% and 59%.

For patients with chronic obstructive pulmonary disorder, the probability of cost effectiveness of NIV was much higher (82–87%).

Future trials with extended follow-up are needed to reduce uncertainty surrounding the long-term cost effectiveness of NIV.