Table 1.
Genetic determinants of fluoroquinolone resistance in the Indian isolates
| Source |
S. Typhi (n=101) |
S. Paratyphi A (n=14) |
Total | ||
|---|---|---|---|---|---|
| adults | children | adults | children | ||
| Number of isolates | 68 | 33 | 10 | 4 | 115 |
| Fluoroquinolone non-susceptible | 67 (99%) | 31 (94%) | 9 (90%) | 3 (75%) | 110 (96%) |
| Any QRDR mutation | 67 (99%) | 32 (97%) | 10 (100%) | 4 (100%) | 113 (98%) |
| 3 QRDR mutations (gyrA S83F, gyrA D87N, parC S80I) | 12 (18%) | 9 (27%) | 0 | 0 | 21 (18%) |
| 2 QRDR mutations | 12 (18%) | 4 (12%) | 0 | 0 | 16 (14%) |
| gyrA S83F, parC E84G | 6 (9%) | 3 (9%) | 0 | 0 | |
| gyrA S83F, parE A364V | 4 (6%) | 1 (3%) | 0 | 0 | |
| gyrA S83Y, parE A364V | 1 (1%) | 0 | 0 | 0 | |
| gyrA D87N, parE A364V | 1 (1%) | 0 | 0 | 0 | |
| 1 QRDR mutation | 43 (63%) | 19 (58%) | 10 (100%) | 4 (100%) | 74 (64%) |
| gyrA S83F | 7 (10%) | 4 (12%) | 7 (70%) | 3 (75%) | |
| gyrA S83Y | 34 (50%) | 15 (45%) | 3 (30%) | 1 (25%) | |
| gyrA D87N | 1 (1%) | 0 | 0 | 0 | |
| gyrB S464F | 1 (1%) | 0 | 0 | 0 | |