Table 1.
Patient and tumour characteristics by symptom type for continuous variables, figures in table represent median (range) with corresponding p value from the Kruskal-Wallis test and for categorical variables, figures in table represent n (%) with corresponding p value from the χ2 test
| Characteristic | No RCC-type symptoms (n=186) | RCC-type symptoms reported (n=422)† | |||
| Not RCC related (n=183) | RCC-related local symptoms only (n=97) | RCC-related systemic symptoms (±local) (n=124) | P value | ||
| Age (years) | 65 (31–86) | 63 (29–90) | 63 (38–84) | 62 (33–92) | 0.31 |
| Gender | |||||
| Female | 67 (32.7) | 62 (30.2) | 21 (10.2) | 55 (26.8) | |
| Male | 119 (30.9) | 121 (31.4) | 76 (19.7) | 69 (17.9) | 0.01 |
| BMI | 28.5 (15.6–74.4) | 27 (18.1–56.5) | 28.8 (17.3–67.2) | 27.5 (16–54.5) | 0.01 |
| Tumour size (mm) | 44 (14–180) | 43 (11–170) | 74 (13–155) | 75 (20–240) | <0.01 |
| pT | |||||
| 1a | 83 (42.6) | 88 (45.1) | 16 (8.2) | 8 (4.1) | |
| 1b | 46 (34.3) | 42 (31.3) | 19 (14.2) | 27 (20.1) | |
| 2 | 15 (19.7) | 18 (23.7) | 19 (25) | 24 (31.6) | |
| 3 | 38 (22.6) | 33 (19.6) | 42 (25) | 55 (32.7) | |
| 4 | 0 (0) | 0 (0) | 1 (25) | 3 (75) | |
| X | 1 (50) | 1 (50) | 0 (0) | 0 (0) | |
| Missing | 1 (100) | 0 (0) | 0 (0) | 0 (0) | |
| NA | 2 (20) | 1 (10) | 0 (0) | 7 (70) | <0.01 |
| Grade | |||||
| 1 | 4 (40) | 0 (0) | 4 (40) | 2 (20) | |
| 2 | 55 (34.8) | 50 (31.6) | 25 (15.8) | 28 (17.7) | |
| 3 | 88 (32.2) | 94 (34.4) | 47 (17.2) | 44 (16.1) | |
| 4 | 13 (14.9) | 13 (14.9) | 19 (21.8) | 42 (48.3) | |
| Missing | 9 (39.1) | 9 (39.1) | 1 (4.3) | 4 (17.4) | |
| NA | 17 (43.6) | 17 (43.6) | 1 (2.6) | 4 (10.3) | <0.01 |
| Stage | |||||
| I | 130 (39.8) | 129 (39.4) | 34 (10.4) | 34 (10.4) | |
| II | 12 (17.4) | 17 (24.6) | 18 (26.1) | 22 (31.9) | |
| III | 34 (24.5) | 29 (20.9) | 37 (26.6) | 39 (28.1) | |
| IV | 10 (18.9) | 6 (11.3) | 8 (15.1) | 29 (54.7) | |
| Missing | 0 (0) | 2 (100) | 0 (0) | 0 (0) | <0.01 |
| Tumour subtype | |||||
| Clear cell | 147 (31.7) | 137 (29.6) | 83 (17.9) | 96 (20.7) | |
| Papillary | 16 (27.1) | 23 (39) | 7 (11.9) | 13 (22) | |
| Chromophobe | 15 (32.6) | 15 (30.4) | 7 (15.2) | 10 (21.7) | |
| Unclassified | 7 (38.9) | 6 (33.3) | 0 (0) | 5 (27.8) | |
| Other | 1 (33) | 2 (67) | 0 (0) | 0 (0) | 0.81 |
*Not applicable (NA)—patients underwent biopsy only or tumour ablation.
†18 patients reported symptoms but their relationship to RCC could not be determined.
BMI, body mass index; RCC, renal cell carcinoma.