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Representative figure of PCNA immunolocalization (red), histochemical detection of differentiated cells (blue) and in situ detection of apoptotic cells (brown). The apical part of the complex folds was characterized by a low PCNA expression, few round apoptotic cells and a strong alkaline phosphatase signal (A,B). In contrast, high proliferation and high apoptotic rate associated with low alkaline phosphatase expression in the basal part of the complex folds were observed (C,D).
