Table 2.

In vitro α-amylase inhibitory activity of indeno[1,2-c]pyrazol-4-ones (4a–o)

Compounds	R1	R2	% Inhibition				IC50 (μg/mL)
			12.5 (μg/mL)	25 (μg/mL)	50 (μg/mL)	100 (μg/mL)
4a	CH3	H	36.42	47.14	85.00	89.28	21.23
4b	CH3	CH3	7.14	15.71	70.71	82.14	40.46
4c	CH3	OCH3	28.57	37.14	63.57	87.14	31.28
4d	CH3	Cl	22.14	50.71	72.14	85.71	26.44
4e	CH3	Br	37.85	59.28	73.57	86.42	19.25
4f	CH(CH3)2	H	19.28	55.00	60.00	77.14	30.61
4g	CH(CH3)2	CH3	15.714	31.42	41.42	58.57	68.36
4h	CH(CH3)2	OCH3	22.85	36.42	65.71	72.85	35.8
4i	CH(CH3)2	Cl	57.85	67.14	73.57	92.14	11.90
4j	CH(CH3)2	Br	28.57	39.28	50.71	81.42	36.44
4k	CH2CH(CH3)2	H	16.42	31.42	66.42	77.14	37.62
4l	CH2CH(CH3)2	CH3	31.42	55.71	67.14	82.14	23.71
4m	CH2CH(CH3)2	OCH3	25.71	40.71	57.85	83.57	33.36
4n	CH2CH(CH3)2	Cl	24.28	45.71	61.42	73.57	33.14
4o	CH2CH(CH3)2	Br	54.28	65.71	78.57	82.14	12.83
Acarbose	‒	‒	30.71	51.42	75.71	92.14	22.87