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. 2020 May 5;8(1):e000368. doi: 10.1136/jitc-2019-000368

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© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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Modulation of different T-cell populations for mCRPC and melanoma patients with treatment. T-cell counts for specific populations were assessed by flow cytometry pretreatment after one cycle of treatmemt. (A) The count of CD4+ T cells. (B) The count of CD8+ T cells. (C) The count of CD25+ T cells. (D) The count of CD69+ T cells. (E) The count of CD127+ T cells. (F) The count of PD1+ T cells. (G) The count of CD25+CD69+CD127+PD1− T cells. (H) The count of CD25−CD69+CD127+PD1+ T cells. (I) The count of CD25−CD69+CD127+PD1− T cells. (J) The count of CD25−CD69−CD127+PD1+ populations. Each figure has two panels representing mCRPC (left) and metastatic melanoma (right). Each panel plots the population count at baseline and on-treatment with connected lines for each patient. The figures with * indicate that there is a significant difference in the ratio of on-treatment count and baseline count of each respective T-cell population between mCRPC and melanoma patients (p<0.05). mCRPC, metastatic castration resistant prostate cancer.