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editorial
. 2019 Nov 26;46(1):116–118. doi: 10.1007/s00134-019-05874-w

Table 1.

Ongoing ICU trials likely randomising subgroups of patients with sepsis to higher vs. lower oxygenation targets

Trial acronym Identifier Population Sample size Higher O2 target Lower O2 target Status
HOT-ICU NCT 03174002 ICU patient with acute hypoxia within 12-h of ICU admission 2928 PaO2 90 mmHg PaO2 60 mmHg

Recruiting-estimated completion June 2020

Interim analysis past (50% of patients)
O2-ICU NCT 02321072 ICU patients with ≥ 2 positive SIRS-criteria and an expected ICU stay > 48 h 385 PaO2 120 (105−135) mmHg PaO2 75 (60-90) mmHg Recruiting-estimated completion Dec 2019
LOCO2 NCT 02713451 ICU patients with ARDS ventilated < 12 h 206 planned 850 PaO2 (90–105) mmHg PaO2 (55−70) mmHg  Terminated for safety reasons
TOXYC NCT 03287466 ICU patients who are expected to be mechanically ventilated > 24 h 60 Standard care SpO2 (88–92%) Recruiting-estimated completion Dec 2019

ARDS acute respiratory distress syndrome, SIRS systemic inflammatory response syndrome; Data obtained from clinicaltrials.gov (Webpage accessed on 11 November 2019)