Table 2.
Comparison of clinical and laboratory findings between MC4R variants detected and undetected patients
| MC4R (−) n (127) | MC4R (+) n (12) | ||
|---|---|---|---|
| Features | Mean ± SDS | Mean ± SDS | p |
| Age (years) | 8.1 ± 2.3 | 7.8 ± 5.2 | 0.17 |
| Age of onset of obesity | 4.7 ± 2.9 | 2.2 ± 1.1 | 0.01 |
| Height SDS | 1.4 ± 0.9 | 1.2 ± 1.4 | 0.22 |
| BMI (kg/m2) | 37.1 ± 10.5 | 42.2 ± 9.9 | 0.15 |
| BMI SDS | 3.6 ± 0.8 | 3.8 ± 1.5 | 0.16 |
| Systolic blood pressure (mmHg) | 97.3 ± 32.0 | 93.9 ± 21.1 | 0.45 |
| Diastolic blood pressure (mmHg) | 64.4 ± 28.0 | 62.7 ± 26.3 | 0.57 |
| Fasting glucose (mg/dL) | 85.6 ± 10.7 | 89.9 ± 10.2 | 0.54 |
| Fasting insulin (mIU/ml) | 17.8 ± 11.9 | 20.2 ± 11.9 | 0.21 |
| HOMA-IR | 3.9 ± 2.6 | 5.4 ± 1.8 | 0.04 |
| HbA1c (%) | 5.4 ± 0.5 | 5.5 ± 0.7 | 0.66 |
| Total cholesterol (mg/dL) | 189.3 ± 78.1 | 191.7 ± 82.1 | 0.76 |
| Triglycerides (mg/dL) | 153.2 ± 66.2 | 167.1 ± 62.6 | 0.88 |
| HDL (mg/dl) | 41.6 ± 9.8 | 40.2 ± 10.2 | 0.97 |
MC4R melanocortin 4 receptor, SDS standard deviation score, HOMA-IR homeostasis model assessment-insulin resistance, BMI body mass index, HDL high density lipoprotein