Table 1.
List of important chikunguniya antibodies along with the species isolation method and efficacy in animal studies
| Ab Name | Origin | Acute/convalescent | Isolation technique | Epitope | In vivo exp | Efficacy | Ref |
|---|---|---|---|---|---|---|---|
| 4 N12 | Human | 5 years infection | B cell Hybridoma | E2 | Mice | +++ | Smith et al. (2015) |
| 2B4 | Human | 5 years infection | B cell Hybridoma | E2 | +++ | Smith et al. (2015) | |
| 2H1 | Human | 5 years infection | B cell Hybridoma | E2-DA | – | +++ | Smith et al. (2015) |
| 1H12 | Human | 5 years infection | B cell Hybridoma | E2-DA/dB | – | +++ | Smith et al. (2015) |
| 8G18 | Human | 5 years infection | B cell Hybridoma | E2-DA | – | ++ | Smith et al. (2015) |
| 3E23 | Human | 5 years infection | B cell Hybridoma | E2-DA | Mice | ++ | Smith et al. (2015) |
| 1O6 | Human | 5 years infection | B cell Hybridoma | E2-DA | Smith et al. (2015) | ||
| 4 J21 | Human | 5 years infection | B cell Hybridoma | E2-DA/DB | Mice | +++ | Long et al. (2015); Smith et al. (2015) |
| 5 M16 | Human | 5 years infection | B cell Hybridoma | E2-DA/DB | Mice | +++ | Long et al. (2015); Smith et al. (2015) |
| 9D14 | Human | 5 years infection | B cell Hybridoma | – | Mice | +++ | Smith et al. (2015) |
| 8I4 | Human | 5 years infection | B cell Hybridoma | E2-DA/DB | – | +++ | Smith et al. (2015) |
| 4B8 | Human | 5 years infection | B cell Hybridoma | – | Mice | +++ | Smith et al. (2015) |
| 2D12 | Human | 5 years infection | B cell Hybridoma | E2 | Mice | + | Smith et al. (2015) |
| 5F10 | Human | 6 weeks infection | B cell Hybridoma | E2-DB | Mice | ++ | Fric et al. (2013); Lee et al. (2011); Selvarajah et al. (2013); Warter et al. (2011) |
| 8B10 | Human | 6 weeks infection | B cell Hybridoma | E2-DA/DB | Mice | ++ | Fric et al. (2013); Lee et al. (2011); Selvarajah et al. (2013); Warter et al. (2011) |
| C9 | Human | Convalascent | EBV transformation of PBMC | E2 | Mice | ++ | Jin et al. (2015); Selvarajah et al. (2013) |
| IM-CKV063 | Human | 2–3 years infection | Phage Library from PBMC | E2-DA/DB | Mice | +++ | Fong et al. (2014); Jin et al. (2015); Selvarajah et al. (2013) |
| m242 | Mouse | Immunized mice | Hybridoma | E2-DA | – | – | Sun et al. (2013) |
| m10 | Mouse | Immunized mice | Hybridoma | E2-DB | – | – | Sun et al. (2013) |
| CHKW-24 | Human | > 5 years infection | Human Hybridoma | Mice/primates | +++ | Kose et al. (2019) | |
| CK47 | Mouse | Immunized mice | Spelnocyte Hybridoma | E1-DIII | – | ++ | Masrinoul et al. (2014) |
| CHK-102 | Mouse | Immunized mice | Spelnocyte Hybridoma | – | Mice | +++ | Pal et al. (2013) |
| CHK-152 | Mouse | Immunized mice | Spelnocyte Hybridoma | E2-DA/DB |
Mice /Primate |
+++ | Fox et al. (2019); Hawman et al. (2013); Pal et al. (2013); Pal et al. (2014) |
| CHK-9 | Mouse | Immunized mice | Spelnocyte Hybridoma | E2-DA/DB | – | ++ | Pal et al. (2013) |
| CHK-166 | Mouse | Immunized mice | Spelnocyte Hybridoma | E1-DII | Mice/primate | ++ | Fox et al. (2019); Hawman et al. (2013); Pal et al. (2014) |
| CHK-263 | Mouse | Immunized mice | Spelnocyte Hybridoma | – | Mice | +++ | Pal et al. (2013) |
| CHK-265 | Mouse | Immunized mice | Spelnocyte Hybridoma | E2-DA/DB | Mice | Fox et al. (2015); Kielian and Saphire (2015); Pal et al. (2013) | |
| CHK-187 | Mouse | Immunized mice | Spelnocyte Hybridoma | E2-DB | Mice | ++ | Fox et al. (2015); Pal et al. (2013) |
| Single Domain antibodies CA6,CC3 (sdAbs) | Llamas | Immunized llamas | Phage display library | E1 | – | – | Liu et al. (2019) |