Fig. 4.

Linear regression analysis of pressure-flow relationships during [1], and after [2] use of mannitol, hypertonic saline, and hyperventilation to manage intracranial hypertension. The critical closing pressure (CrCP) is represented by the intercept of the regression line with the x-axis. CrCP for 1 = 60, CrCP for 2 = 72.9. CrCP high due to increased ICP. Increasing CrCP could be partially caused by increased cerebrovascular resistance from reducing partial pressure of carbon dioxide, but a lack of reduction in CrCP is consistent with an ICP that continued to increase despite treatment