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. 2020 May 5;8(1):e000617. doi: 10.1136/jitc-2020-000617

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© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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Association of ICR with nonsilent mutation rate, predicted neoantigen load, and tumor aneuploidy. (A) Scatter plot of log transformed non-silent mutation count per ICR cluster for each cancer type. (B) Log transformed predicated neoantigen load per ICR cluster for each cancer type. (A, B) Red cross-bar represents the mean value per ICR cluster. Cancer types are ordered by mean nonsilent mutation count per cancer. Non-silent mutation rate and predicted neoantigen load were obtained from Thorsson et al.7 (C) Correlation between aneuploidy score and raw/purity adjusted ICR score for all cohorts with significant relationships between ICR and aneuploidy. ICR, immunological constant of rejection.