Table 2.
Primary outcome and key secondary outcomes
| Conservative oxygen (n = 130) | Usual oxygen (n = 121) | Estimatea (95% CI) | ||
|---|---|---|---|---|
| Primary outcome and key secondary outcomes |
Odds ratio; P value | |||
| Unadjusted | Adjustedb | |||
| 90-day mortality, n/N (%) | 47/130 (36.2%) | 35/120 (29.2%) | 1.38 (0.81–2.34); P = 0.24 | 1.29 (0.73–2.3); P = 0.38 |
| 180-day mortality, n/N (%) | 47/130 (36.2%) | 39/118 (33.1%) | 1.16 (0.69–1.96); P = 0.58 | 1.02 (0.57–1.82); P = 0.94 |
| Died in ICU, n/N (%) | 34/119 (28.6%) | 22/115 (19.1%) | 1.69 (0.92–3.12); P = 0.09 | 1.6 (0.83–3.09); P = 0.16 |
| Died in hospital, n/N (%) | 43/130 (33.1%) | 31/121 (25.6%) | 1.43 (0.83–2.48); P = 0.2 | 1.4 (0.77–2.53); P = 0.27 |
| Difference in Medians‡ | P value | |||
|---|---|---|---|---|
| ICU length of stay (days), median (IQR) | 6.1 [3–13.3] | 5.7 [3.1–9.6] | 0.3 [− 1.6 to 2.1] | 0.53 |
| Hospital length of stay (days), median (IQR) | 15 [6.9–26.7] | 13.1 [8.0–26.4] | 1.9 [− 2.7 to 6.5] | 0.99 |
| Vasopressor-free days, median (IQR) | 22 [0–26] | 24.0 [6–26] | 0.0 [− 0.9 to 0.9] | 0.16 |
| Ventilator-free days, median (IQR) | 19.3 [0–26.2] | 22.9 [0–25.9] | − 3.5 [− 9.5 to 2.6] | 0.26 |
| Odds ratio (unadjusted) | P value | |||
|---|---|---|---|---|
| Patients receiving RRT in ICU, n/N (%) | 48/130 (36.9%) | 41/121 (33.9%) | 1.14 (0.68–1.92) | P = 0.62 |
| Cause-specific mortality, n/N (%)c | P value = 0.29 | |||
| Arrhythmia | 1/48 (2.1%) | 0/39 (0%) | ||
| Brain damage | 4/48 (8.3%) | 3/39 (7.7%) | ||
| Cardiogenic shock | 1/48 (2.1%) | 6/39 (15.4%) | ||
| Distributive shock | 27/48 (56.3%) | 17/39 (43.6%) | ||
| Hypovolemic shock | 0/48 (0%) | 1/39 (2.6%) | ||
| Hypoxic respiratory failure | 12/48 (25%) | 9/39 (23.1%) | ||
| Metabolic | 3/48 (6.3%) | 2/39 (5.1%) | ||
| Other | 0/48 (0%) | 1/39 (2.6%) | ||
IQR Interquartile range, CI confidence interval, RRT renal replacement therapy
‡All differences in medians [95% CI] were calculated using quantile regression
aThe widths of the confidence intervals for secondary analyses have not been adjusted for multiplicity and the intervals should not be used to infer definite differences between the groups
bAdjusted for age, gender, site, and APACHE II score
cIncludes one patient in the conservative oxygen group who died after 180-day