Table 2.
Reported peptides sequences from plants for antidiabetic activity
| Sr. no | Plants | Sequences | Target | Study | References |
|---|---|---|---|---|---|
| 1 | Amaranthus hypochondriacus L. |
PPPP, GP, PP, MP, VA, MA, KA, LA, FA, AP, FP, PA, LP, VP, LL, VV, HA, IPA, IPI |
DPP-IV inhibition | In vitro | Velarde-Salcedo et al. (2013) |
| 2 |
Cannabis sativa L. (Hemp). |
LR and PLMLP | Alpha-glucosidase inhibitory | In vitro | Ren et al. (2016) |
| 3 |
Phaseolus vulgaris L. (Pinto) |
PPHMLP, PPMHLP, PLPWGAGF, GNAACCGLPLLP, PPHMGGP, PLPPHALL, PAPFPSPHTP | alpha-amylase inhibitory | In vitro | Ngoh and Gan (2016) |
| 4 |
Oryza sativa L. (Rice bran) |
LP, IP, MP, VP | DPP-IV inhibition | In vitro | Hatanaka et al. (2012, 2015) |
| 5 |
Glycine max L. (Soy) and Lupinus albus L. (Lupin) |
IAVPTGVA, YVVNPDNDEN, YVVNPDNNEN, LTFPGSAED, LILPKHSDAD, GQEQSHQDEGVIVR | DPP-IV inhibition | In vitro | Lammi et al. (2016) |
| 6 |
Phaseolus vulgaris L. (Common bean) |
AKSPLF, ATNPLF, FEELN, and LSVSVL | (GLUT2) inhibitor, (SGLT1) inhibitor | In vitro and in vivo | Mojica et al. (2017a) |
| 7 |
Avena sativa L. (Oat) |
FLQPNLDEH, DLELQNNVFPH, and TPNAGVSGAAAGAGAGGKH |
Alpha-glucosidase activity | In vitro and in vivo | Zhang et al. (2015) |
| 8 | Momordica charantia L. | GHPYYSIKKS | Hypoglycemic | In vivo | Yuan et al. (2008) |
| 9 |
Phaseolus vulgaris L. (Common bean) |
LLSL, QQEG, and NEGEAH | alpha-glucosidase inhibition, amylase inhibition | In vitro | Oseguera-Toledo et al. (2015) |
| 10 |
Cuminum cyminum L. (Cumin) |
FFRSKLLSDGAAAAKGALLPQYW, RCMAFLLSDGAAAAQQLLPQYW, and DPAQPNYPWTAVLVFRH | alpha -amylase inhibition | In vitro | Siow and Gan (2016) |
| 11. |
Phaseolus vulgaris L. (Common bean) |
TTGGKGGK | alpha-glucosidase inhibition | In vitro and In silico | Mojica and de Mejía (2016) |
| 12 | Chenopodium quinoa Wild. |
IQAEGGLT, DKDYPK, GEHGSDGNV |
Alpha-glucosidase inhibition, alpha -amylase inhibition, DPP- IV inhibitor |
In vitro | Vilcacundo et al. (2017) |
| 13. |
Morus alba L. (Mulberry) |
WGYENAATYFWQTV | alpha-glucosidase inhibition | In vitro | Jha et al. (2018) |
| 14. | Glycine max L. | YPFVV | Hypoglycemic | In vivo | Yamada et al. (2011) |
G glycine, A alanine, L leucine, M methionine, F phenylalanine, W tryptophan, K lysine, Q glutamine, E glutamic acid, S serine, P proline, V valine, I isoleucine, C cysteine, Y tyrosine, H histidine, R arginine, N asparagine, D aspartic acid, T threonine, kDa kilo dalton