Table 3.
Reported protein hydrolysate from plants for antidiabetic activity
| Sr. no. | Plants | Part used | Activities | Studies | References |
|---|---|---|---|---|---|
| 1 | Juglans mandshurica Maxim. | Fruits | alpha-glucosidase inhibition, reduce fasting blood glucose levels, increase in insulin secretion, liver glucokinase and glycogen levels | In vitro and in vivo | Wang et al. (2018) |
| 2 | Hordeum vulgare L. | Seeds | alpha-amylase inhibition | In vitro | Alu’datt et al. (2012) |
| 3 | Spinacia oleracea L. and Lemna gibba G3 | Leaves and whole plant | Insulin mimetics | In vitro | Collier et al. (1987) |
| 4 | Vigna angularis Wild. | Seeds | alpha-glucosidase inhibition | In vivo | (Yao et al. 2014) |
| 5 | Triticum aestivum L. | Seeds | alpha-amylase inhibition | In vitro | Kodama et al. (2005) |
| 6 | Linum usitatissimum L. | Seeds | Increase glucose uptake | In vitro | Doyen et al. (2014) |
| 7 | Glycine max L. | Seeds | Increase glucose uptake in muscular cells via AMK activation | In vitro | Roblet et al. (2014) |
| 8 | Phalaris canariensis L | Seeds | DPP4 inhibition | In vitro | Estrada-Salas et al. (2014) |
| 9 | Vigna unguiculata L. | Seeds | Insulin mimetic | In vitro | Uruakp (2015) |
| 10 | Momordica cymbalaria Hook.f. | Fruits | alpha-glucosidase inhibition | In vitro and in vivo | Marella et al. (2016) |
| 11 | Cucurbita pepo L. | Seeds | alpha-amylase inhibitory | In vitro | (Vaštag et al. 2014) |
| 12 | Moringa oleifera Lam. | Seeds | alpha-amylase inhibitory | In vitro | (Gonzalez Garza et al. 2017) |
| 13 | Citrullus lanatus L. | Seeds | alpha-amylase inhibitory | In vitro | Arise (2016) |
| 14 | Theobroma cacao L. | Fruits | alpha-amylase inhibitory | In vivo | Sarmadi et al. (2012) |
| 15 | Phaseolus vulgaris L. | Seeds | DPP- IV inhibitor | In vitro | Mojica et al. (2017b) |
| 16 | Chenopodium quinoa Willd. | Seeds | DPP- IV inhibitor | In vitro | Nongonierma et al. (2015) |
| 17 | Momordica charantia L. | Fruit pulp | Insulin secretagogue and insulinomimetic | In vivo and in vivo | Yibchok-Anun et al. (2006) |
| 18 | Momordica charantia L. | Fruits, seeds | Insulin mimetic | In vivo | (Khanna et al. 1981) |
| 19 | Momordica charantia L. | Seed protein expressed in E.coli | Stimulated the phosphorylation of PDK1 and Akt, enhanced expression of GLUT-4, stimulated both the uptake of glucose in cells and the clearance of glucose | In vitro and in vivo | Lo et al. (2016) |
| 20 | Momordica cymbalaria Hook.f. | Fruits | Hypoglycemic | In vivo | Rajasekhar et al. (2010) |
| 21 |
Telfairia occidentalis Hook.f. Citrullus lanatus L. Lagenaria siceraria Molina. Cucurbita moschata Duchesne. |
Seeds | Hypoglycemic | In vivo | Teugwa et al. (2013) |
| 22 | Zea mays L. |
Seed protein (Zein) hydrolysate |
Enhance the secretion of GLP-1 | In vivo | Hira et al. (2009) |
| 23 | Glycine max L. | Seeds | Increases the glucose uptake, enhance the expression of p-IR, p-IRS1, p-Akt and membrane GLUT4 protein improve the insulin resistance hypoglycemic | In vitro and in vivo | Lu et al. (2012) |
| 24 | Oryza sativa L. | Rice bran | Improve insulin resistance | In vivo | Boonloh et al. (2015) |
| 25 | Momordica dioica Roxb. | Fruits | Hypoglycemic | In vivo | Poovitha et al. (2017) |