Fig. 4.

Interferon-gamma is critical for tumor control following vaccination. a Tumor growth in IFNγ-/- mice and b percent survival were monitored for the duration of the experiment. Data are presented as mean ± SEM where n = 10 mice/group from one representative experiment of two equivalent experiments. Statistical significance in tumor growth a was determined using a two-way ANOVA with Tukey’s multiple comparisons test. Percent survival b was plotted as a Kaplan–Meier curve and the log-rank (Mantel–Cox) test was used to calculate statistical significance. p < 0.05*, p < 0.01**, p < 0.001*** and p < 0.0001****. IMX = ISCOMATRIX® adjuvant