Fig. 5.

IMX–mPAP + Poly I:C–Flt3 vaccine protects against both solid and non-solid cancers. a Prostates and seminal vesicles weights of vaccinated TRAMP Tg mice and littermate controls at week 15 or weeks 21–24. Data are presented as mean ± SEM where n = 22–30 mice/group pooled from eleven experiments. Statistical significance was determined using a one-way ANOVA using Tukey’s multiple comparisons test. p < 0.01**. b B16-OVA tumor growth and c Percent survival d Eµ-myc-GFP-OA lymphoma growth and e percent survival. Statistical significance was determined using a one-way ANOVA using Tukey’s multiple comparisons test. Data are presented as mean ± SEM where n = 10 (b, c) or n = 5 (d, e) mice/group from one representative experiment of three equivalent experiments. Statistical significance in tumor growth b was determined using a two-way ANOVA with Tukey’s multiple comparisons test. Percent survival c, d) was plotted as a Kaplan–Meier curve and the log-rank (Mantel–Cox) test was used to calculate statistical significance. p < 0.05*, p < 0.01**, p < 0.001*** and p < 0.0001****. IMX = ISCOMATRIX® adjuvant