. 2018 Nov 1;35(2):213–220. doi: 10.1007/s00467-018-4128-7

Table 1.

Comparing Outcomes from AWARE and AWAKEN [6, 19]

	AKI definition	n	Mortality	Length of stay, median (IQR)	Mechanical ventilation
AWARE [6]	KDIGO	4683	• AKI: 6.5% • AKI: 11%^* • No AKI: 2.4% • adjusted OR^ǂ: 1.8 (1.2–2.7)	• No AKI: 2 days (1–4) • Stage 1 AKI: 3 days (2–7)^* • Stage 2 AKI: 4 days (2–8)^* • Stage 3 AKI: 5 days (2–11)^*	• No AKI: 29.5% • Stage 1 AKI: 38.2%^* • Stage 2 AKI: 40.5%^* • Stage 3 AKI: 50.2%^*
AWAKEN [19]	Modified KDIGO	2022	• AKI: 10%^* • No AKI: 1% • adjusted OR: 4.6 (2.5–8.3)	• No-AKI: 19 days (9–36) • AKI: 23 days (10–61)^*	N/A

AKI definition

Mortality

Length of stay, median (IQR)

Mechanical ventilation

AWARE [6]

KDIGO

4683

• AKI: 6.5%

• AKI: 11%^*

• No AKI: 2.4%

• adjusted OR^ǂ: 1.8 (1.2–2.7)

• No AKI: 2 days (1–4)

• Stage 1 AKI: 3 days (2–7)^*

• Stage 2 AKI: 4 days (2–8)^*

• Stage 3 AKI: 5 days (2–11)^*

• No AKI: 29.5%

• Stage 1 AKI: 38.2%^*

• Stage 2 AKI: 40.5%^*

• Stage 3 AKI: 50.2%^*

AWAKEN [19]

Modified KDIGO

2022

• AKI: 10%^*

• No AKI: 1%

• adjusted OR: 4.6 (2.5–8.3)

• No-AKI: 19 days (9–36)

• AKI: 23 days (10–61)^*

N/A

The in-hospital outcome results from the Assessment of Worldwide Acute Kidney Injury, Renal Angina, and Epidemiology (AWARE) and Assessment of Worldwide Acute Kidney Injury Epidemiology in Neonates (AWAKEN) studies are presented in Table 1

*p < 0.001 vs. no-AKI

ǂSevere AKI vs. no severe AKI

AKI acute kidney injury