Table 2.
Results of laboratory, radiographic, ophthalmologic, and audiologic evaluation in 34 infants with congenital CMV infection and a normal physical examination at birth
| Dallas | Buenos Aires | Total | |
|---|---|---|---|
| No. of infants | 14 (41%) | 20 (59%) | 34 |
| No. of infants with at least 1 abnormality | 7 (50%) | 12 (60%) | 19 (56%) |
| Laboratory evaluation | 10 (71%) | 15 (75%) | 25 (71%) |
| Any abnormality | 4 (40%) | 11 (73%) | 15 (60%) |
| Complete blood cell count | 10 (40%) | 15 (60%) | 25 (100%) |
|
Anemia (hematocrit; mean, range) |
0 |
3 (20%) (35%, 30–39%) |
3 (12%) (35%, 30–39%) |
|
Thrombocytopenia (#/ml; mean, range) |
2 (20%) (33,500; 10,000–57,000) |
2 (13%) (126,000; 114,000–132,000) |
4 (16%) (78,250; 10,000–132,000) |
| Hepatic assessment | 8 (57%) | 15 (75%) | 23 (92%) |
|
Elevated alanine aminotransferase (U/mL; mean, range) |
2 (22%) (44.5, 43–46) |
7 (78%) (55.5, 41–74) |
9 (39%) (53, 41–74) |
| Direct hyperbilirubinemia | 0 | 0 | 0 |
| Neuroimaging | 14 (100%) | 10 (50%) | 24 (71%) |
| Any abnormality | 6 (43%) | 5 (57%) | 11 (46%) |
| Cranial ultrasonography | 13 (93%) | 9 (90%) | 22 (92%) |
| Any abnormality | 6 (46%) | 4 (44%) | 10 (45%) |
| Diffuse calcifications | 1 (8%) | 0 | 1 (55%) |
| Lenticulostriate vasculopathy | 2 (14%) | 3 (30%) | 5 (23%) |
| Ventriculomegaly | 1 (8%) | 0 | 1 (5%) |
| Any Grade of IVH | 5 (39%) | 1 (11%) | 6 (27%) |
| Grade I IVH | 5 (100%) | 0 | 5 (83%) |
| Grade II–III IVHa | 0 | 1 (100%) | 1 (17%) |
| Cranial computerized tomography | 1 (7%) | 1 (10%) | 2/24 (8%) |
| Thalamic calcifications | 0 | 1 (100%) | 1 (50%) |
| Brain magnetic resonance imaging | 2 (14%) | 5 (50%) | 7/24 (29%) |
| Periventricular calcifications and temporal lobe hyperlucency | 0 | 1 (20%) | 1 (14%) |
| Calcifications of thalami | 0 | 1 (20%) | 1 (14%) |
| Germinal matrix hemorrhage | 1 (50%) | 0 | 1 (14%) |
| Ophthalmological evaluation | 13 (93%) | 20 (100%) | 33 (97%) |
| Chorioretinitis | 0 | 1 (5%) | 1 (3%) |
| Audiologic evaluation (brainstem evoked responses) | 14 (100%) | 20 (100%) | 34 (100%) |
| Sensorineural hearing loss | 6 (43%) | 1 (5%) | 7 (21%) |
| Unilateral | 3 (50%) | 1 (100%) | 4 (57%) |
| Bilateral | 3 (50%) | 0 | 3 (43%) |
| Mild | 1 (17%) | 0 | 1 (14%) |
| Moderate | 2 (33%) | 0 | 2 (29%) |
| Severe-profound | 3 (50%) | 1 (100%) | 4 (57%) |
aNeonate born at 27 weeks’ gestation