Table 1.
Baseline Characteristics Stratified by Clinical Categories of Thyroid Dysfunction, ARIC 1990 - 1992
| Risk factors | Hypothyroidism |
Euthyroidism (n = 10,956) | Hyperthyroidism |
||
|---|---|---|---|---|---|
| Overt (n = 281) | Subclinical (n = 581) | Subclinical (n = 429) | Overt (n = 234) | ||
| TSH > 5.1 mIU/L; FT4 < 0.85 ng/dL | TSH > 5.1 mIU/L; FT4 = 0.85 - 1.4 ng/dL | TSH = 0.56 - 5.1 mIU/L; FT4 = 0.85 - 1.4 ng/dL | TSH < 0.56 mIU/L; FT4 = 0.85 - 1.4 ng/dL | TSH < 0.56 mIU/L; FT4 > 1.4 ng/dL | |
| Age, years | 58.4 ± 5.4 | 58.4 ± 5.7 | 56.8 ± 5.7 | 56.5 ± 5.8 | 57.1 ± 5.8 |
| Men, % | 22.8 | 33.4 | 45.9 | 33.6 | 19.7 |
| African American, % | 12.8 | 11.0 | 25.1 | 41.5 | 23.1 |
| APOE4 carriers, % | 29.2 | 29.6 | 29.9 | 27.3 | 28.2 |
| Basic educationa, % | 23.1 | 16.8 | 21.5 | 29.2 | 16.2 |
| Family income < $16,000b, % | 24.2 | 21.3 | 25.2 | 34.3 | 22.2 |
| Current alcohol drinker, % | 48.8 | 58.7 | 57.1 | 49.2 | 56.0 |
| Current tobacco smoker, % | 13.9 | 12.9 | 22.3 | 29.6 | 25.2 |
| BMI, kg/m2 | 28.9 ± 5.7 | 27.7 ± 5.5 | 28.0 ± 5.4 | 27.6 ± 5.4 | 27.4 ± 5.4 |
| Hypertensionc, % | 34.1 | 30.9 | 35.8 | 40.0 | 32.6 |
| Diabetesd, % | 7.5 | 10.3 | 11.3 | 15.9 | 12.8 |
| HDL cholesterol, mg/dL | 49.4 ± 16.6 | 49.7 ± 16.3 | 49.4 ± 16.8 | 52.8 ± 17.9 | 52.1 ± 15.7 |
| Total cholesterol, mg/dL | 229.2 ± 48.9 | 214.3 ± 41.2 | 209.7 ± 39.2 | 208.1 ± 38.0 | 199.5 ± 35.2 |
| Prevalent CVDe, % | 8.5 | 8.1 | 8.8 | 11.0 | 9.8 |
| Thyroid medication usef, % | 40.9 | 28.6 | 2.8 | 27.5 | 71.4 |
| TSH, mIU/L | 26.3 ± 32.7 | 8.0 ± 4.4 | 2.0 ± 1.0 | 0.3 ± 0.2 | 0.1 ± 0.2 |
| FT4, ng/dL | 0.7 ± 0.2 | 1.0 ± 0.1 | 1.1 ± 0.1 | 1.2 ± 0.1 | 1.8 ± 0.6 |
| Anti-TPO positive (> 34 IU/L), % | 79.4 | 51.1 | 9.3 | 13.8 | 27.4 |
Mean ± standard deviation.
Based on self-report of some high school education or less at visit 1 (1987 - 1989).
Based on self-report of family income at visit 1 (1987 - 1989).
Defined as diastolic blood pressure ≥ 90 mm Hg, systolic blood pressure ≥ 140 mm Hg, or use of hypertensive medication.
Defined as non-fasting blood glucose ≥ 200 mg/dL, fasting blood glucose ≥ 126 mg/dL, self-report of diabetes, or reporting taking medication for diabetes or high blood sugar.
Defined as prevalent stroke, coronary heart disease, myocardial infarction, or atrial fibrillation at visit 2.
Participants who reported thyroid medication use at baseline. ARIC: Atherosclerosis Risk in Communities; BMI: body mass index; HDL: high-density lipoprotein; CVD: cardiovascular disease; TSH: thyroid-stimulating hormone; FT4: free thyroxine; TPO: thyroid peroxidase.