Table 2.

HRs (95% CI) of Dementia by Anti-TPO Positivity Status, ARIC 1990 - 2017

	Anti-TPO negative ≤ 34 IU/L (number of total = 10,821; number of events = 1,932)	Anti-TPO positive > 34 IU/L (number of total = 1,660; number of events = 303)
Model 1 HR	1 (Ref)	0.92 (0.82 - 1.04)
Model 2 HR	1 (Ref)	0.93 (0.82 - 1.05)
Model 3 HR	1 (Ref)	0.90 (0.80 - 1.03)

Model 1: age, sex, race-center, APOE ε4, income and education. Model 2: model 1 + BMI, smoking status, hypertension, diabetes, drinking status, HDL cholesterol and total cholesterol. Model 3: model 2 + prevalent CVD and baseline thyroid medication use. HR: hazard ratio; CI: confidence interval; TPO: thyroid peroxidase; ARIC: Atherosclerosis Risk in Communities; BMI: body mass index; HDL: high-density lipoprotein; CVD: cardiovascular disease.