. Author manuscript; available in PMC: 2020 May 14.

Published in final edited form as: J Endocrinol Metab. 2019 Aug;9(4):82–89. doi: 10.14740/jem588

Table 3.

HRs (95% CI) of Dementia by Clinical Categories of Thyroid Dysfunction, ARIC 1990 - 2017

	Hypothyroidism		Euthyroidism	Hyperthyroidism
	Overt	Subclinical	Euthyroidism	Subclinical	Overt

	TSH > 5.1 mIU/L; FT4 < 0.85 ng/dL (number of total = 281; number of events = 60)	TSH > 5.1 mIU/L; FT4 = 0.85 - 1.4 ng/dL (number of total = 581; number of events = 98)	TSH= 0.56 - 5.1 mIU/L; FT4 = 0.85 - 1.4 ng/dL (number of total = 10,956; number of events = 1,952)	TSH < 0.56 mIU/L; FT4 = 0.85 - 1.4 ng/dL (number of total = 429; number of events = 74)	TSH < 0.56 mIU/L; FT4 > 1.4 ng/dL (number of total = 234; number of events = 51)
Model 1 HR	1.03 (0.80 - 1.33)	0.78^* (0.64 - 0.96)	1 (Ref)	1.07 (0.85 - 1.35)	1.51^* (1.14 - 1.99)

Model 2 HR	1.01(0.78 - 1.31)	0.76^* (0.61 - 0.93)	1 (Ref)	1.03 (0.81 - 1.31)	1.49^* (1.12 - 1.98)

Model 3 HR	0.96 (0.73 - 1.26)	0.74^* (0.60 - 0.92)	1 (Ref)	1.01 (0.79 - 1.29)	1.40^* (1.02 - 1.92)

P-value < 0.05. Model 1: age, sex, race-center, APOE ε4, income and education. Model 2: model 1 + BMI, smoking status, hypertension, diabetes, drinking status, HDL cholesterol and total cholesterol. Model 3: model 2 + prevalent CVD and baseline thyroid medication use. HR: hazard ratio; CI: confidence interval; ARIC: Atherosclerosis Risk in Communities; BMI: body mass index; HDL: high-density lipoprotein; CVD: cardiovascular disease.