Table 5.
Tracheal aspirate levels of additional inflammatory mediators for infants with apparent response to 0.1 mg/kg budesonide.
| Cyto/chemokine | Number of infants with suppression (n = 7) | % suppression (mean ± SD) | Predose level (suppress/no suppress) |
|---|---|---|---|
| IFN-γ | 3 | 68 ± 18 | 1.9 |
| IL-10 | 3 | 72 ± 21 | 3.7 |
| IL-12p70 | 3 | 69 ± 13 | 3.0 |
| IL-13 | 3 | 69 ± 3 | 5.0 |
| IL-1β | 3 | 64 ± 19 | 4.9 |
| IL-2 | 3 | 72 ± 19 | 2.0 |
| IL-4 | 3 | 65 ± 18 | 1.8 |
| IL-6 | 3 | 56 ± 18 | 4.3 |
| TNF-α | 2 | 51 ± 42 | 3.6 |
| IL-8 | 4 | 79 ± 12 | 5.8 |
| MCP1 | 3 | 54 ± 35 | 5.7 |
| Total | 65 ± 9 | 3.8 ± 1.5 |
Data are by multiplex assay for the first nine mediators and by ELISA for IL-8 and MCP1; suppression occurred in the same infants for each mediator. Apparent suppression was assigned for infants with consistently lower values during treatment compared to predosing with a mean value of >20%.