Fig. 2.

Time to rescue-free laxation within 96 h in the placebo and methylnaltrexone groups. The percentage of participants who had achieved rescue-free laxation at 4 hours post-randomisation was 15.4% (95% CI 7.2%, 31.1%) in the methylnaltrexone group and 7.0% (95% CI 2.3%, 20.1%) in the placebo group. At 12 h post-randomisation the percentage achieving rescue-free laxation had increased to 25.6% (95% CI 14.7%, 42.4%) and 16.5% (95% CI 8.2%, 31.5%) in the methylnaltrexone and placebo groups, respectively. By 72 h post-randomisation the percentage achieving rescue-free laxation had increased to 77.8% (95% CI 60.3%, 91.4%) and 60.0% (95% CI 45.1%, 75.3%) in the methylnaltrexone and placebo groups, respectively