Fig. 4.

Recombinant vaccinia virus titer after challenge of BALB/c mice with vvRE coding for structural region of HCV. Five mice per group, following the immunization schedule of 0, 2, 4, 6 and 10 weeks, were challenged at week 12 with 10⁶ pfu of recombinant vaccinia virus coding for HCV structural protein (vvRE) by intraperitoneal inoculation. The ovaries were collected 5 days after challenge. The bars indicate log₁₀ of the mean viral titer. The asterisks indicate that differences are statistically significant with respect to alum (*, p < 0.05, Kruskal-Wallis test with Dunn’s multiple comparisons as a post-test). The bars represent the standard deviation for each group (5 mice per group)