Table 3.

Animal studies on nebulization and atomization of surfactant.

Author	Year	Method	Deposition	Surfactant	Breathing	Ventilation mode	Animal
Lewis et al.26	1991	Nebulization	2.7%	Survanta	Intubated	IPPV	Lamb
Lewis et al.27	1991	Nebulization	3.6%	Survanta	Intubated	IPPV	Rabbit
Lewis et al.28	1993	Nebulization	6.1%	Survanta	Intubated	IPPV	Sheep
Dijk et al.18	1997	Nebulization	8.4%	Alveofact	Intubated	IPPV	Rabbit
Dijk et al.6	1998	Nebulization	9.8%	Alveofact	Intubated	HFV	Rabbit
Fok et al.29	1998	Nebulization	0.1–1%	Survanta/Exosurf	Intubated	IPPV	Rabbit
Wagner et al.21	2000	Atomization	86.5%	Poractant alfa	Intubated	IPPV	Rabbit
Rahmel et al.20	2012	Aerosolized	1%	rSP-C	Spontaneous	nCPAP	Lamb
Rey-Santano et al.30	2013	Aerosolized	Not reported	Poractant alfa	Intubated	IPPV	Lamb
Linnér et al.14	2015	Nebulization	14%	Poractant alfa	Spontaneous	nCPAP	Pig
Milesi et al.16	2016	Atomization	Not reported	Poractant alfa	Intubated	IPPV	Lamb
Hutten et al. 31	2015	Nebulization	Not significant	Poractant alfa	Spontaneous	nCPAP	Lamb
Milesi et al.22	2017	Atomization	32%	Poractant alfa	Spontaneous	nCPAP	Lamb
Gregory et al. 32	2019	Nebulization	11.4%	Lucinactant	Spontaneous	nCPAP	Macaque