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. 2020 May 14;10:7982. doi: 10.1038/s41598-020-64645-6

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Experimental Design. Japanese PD patients were exposed to a single period of one hour of light at 5,000 lux once a day between 19:00–21:00. This bright light exposure was performed every day for a period of approximately three months in total: one week during hospitalization, more than 10 weeks at home after discharge and one week during re-hospitalization (blue arrow). Before and after the period of bright light exposure, patients completed the UPDRS part III, ESS and PDSS-2, and hair follicles were collected from each patient. w represents week(s).