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. 2020 May 14;11(5):371. doi: 10.1038/s41419-020-2507-z

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Volcano plot of differentially expressed genes. b Relative expression of IMPA2 in cervical cancer tissues (n = 61) compared with that of adjacent normal tissues (n = 61) (P < 0.0001). c Expression of IMPA2 in normal and CESC tissues using public data from the TCGA-CESC dataset (Normal vs Primary tumor: P = 0.0004). d Waterfall plot analyses of IMPA2 mRNA levels in CC and matched non-tumor cervical specimens. Red and blue bars represent samples that show a relative IMPA2 fold change of ≥2 overexpression and underexpression, respectively (CC/NT). e IMPA2 expression was determined using western blotting and qRT-PCR (f) in SiHa and Hela cells. g Immunohistochemical (IHC) detection of IMPA2 in normal cervical samples (NC) and cervical cancer samples and the Immunoreactivity scores of IMPA2 were shown. Scale bar, 100 or 50 μm. Values were all presented as mean values ± SD. *P < 0.05.