Fig. 7.

miR-35 regulates germ cell death by buffering MAPK activity via negative regulation of ndk-1 and by also targeting egl-1 after genotoxic stress. a miR-35 acts to buffer NDK-1 activation of MAPK. Absence of miR-35 result in more cells enriched in NDK-1 protein, which leads to increase in MAPK activity and germ cell death. b Schematic diagram of model for miR-35 inhibition of MAPK and core apoptosis pathway activation. MiR-35 negatively regulates germ cell death by targeting both EGL-1 in the core apoptosis pathway and NDK-1, a positive regulator of MAPK signalling