Table 2. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways and target genes of LUT potentially responsible for the therapeutic activities against cardiotoxicity.

Pathway Classification	Pathway ID	Term	Target Gene
Signal transduction	hsa04066	HIF-1 signaling pathway	AKT1, CASP3, FAS, FGF2, EGFR, MAPK1, MAPK14, VEGFA, MAPK3
Signal transduction	hsa04152	AMPK signaling pathway	AKT1, IGF1R, SLC2A4, PPARG, FASN, IGF1, ADIPOQ, SIRT1
Signal transduction	hsa04150	mTOR signaling pathway	PRKCA, AKT1, MAPK1, TNF, MAPK3, IGF1
Inflammation-generating process	hsa04668	TNF signaling pathway	IL6, TNF, AKT1, MAPK1, CASP3, CASP8, MAPK3, IL1B, FAS
Inflammation-generating process	hsa04370	VEGF signaling pathway	AKT1, MAPK1, PTK2, PTGS2, MAPK14, MAPK3, VEGFA, RAC1, NOS3
Apoptosis	hsa04151	PI3K-Akt signaling pathway	AKT1, BCL2, IL4, IL6, TP53, MAPK1, VEGFA, MAPK3, IL2
Apoptosis	hsa04068	FoxO signaling pathway	IL6, SOD2, AKT1, MAPK1, CDKN1A, SLC2A4, MAPK14, MAPK3, CAT
Apoptosis	hsa04210	Apoptosis	AKT1, CASP3, TNF, BAX, BCL2, CASP8, FAS, ATM
Apoptosis	hsa04115	p53 signaling pathway	CASP3, BAX, CASP8, TP53, IGF1, CDK6, FAS, ATM
Apoptosis	hsa04010	MAPK signaling pathway	TNF, TP53, AKT1, MAPK1, CASP3, MAPK3, FAS, IL1A
Apoptosis	hsa04014	Ras signaling pathway	IGF1, HGF, AKT1, MAPK1, IGF1R, VEGFA, MAPK3, RAC1, FGF1