Table 2.
Among virologically suppressed patients at adherence club entry, crude and adjusted associations with an elevated viral load and confirmed virologic failure, after entry into an adherence club
| First elevated viral load | Confirmed virologic failure | |||||
|---|---|---|---|---|---|---|
| Model 1 HR (95% CI) |
Model 2 aHR (95% CI) (n = 7136) |
Model 3 aHR (95% CI) (n = 4395) |
Model 1 HR (95% CI) |
Model 2 aHR (95% CI) (n = 291) |
Model 3 aHR (95% CI) (n = 219) |
|
| Sex | ||||||
| Male | 1.07 (0.86 to 1.32) | 1.16 (0.93 to 1.44) | 1.11 (0.85 to 1.44) | 1.18 (0.82 to 1.69) | 1.29 (0.88 to 1.90) | 1.29 (0.81 to 2.06) |
| Age group (years) | ||||||
| 16 to 34 | 1.0 | 1.0 | 1.0 | 1.0 | 1.0 | 1.0 |
| 35 to 44 | 0.86 (0.69 to 1.06) | 0.80 (0.64 to 1.00) | 0.70 (0.54 to 0.91) | 1.13 (0.79 to 1.60) | 0.96 (0.66 to 1.39) | 0.96 (0.62 to 1.48) |
| ≥45 | 0.71 (0.55 to 0.93) | 0.66 (0.50 to 0.87) | 0.64 (0.46 to 0.88) | 0.74 (0.45 to 1.19) | 0.61 (0.37 to 1.02) | 0.52 (0.28 to 0.94) |
| Year of AC entry | 0.84 (0.78 to 0.92) | 0.85 (0.78 to 0.92) | 0.76 (0.68 to 0.84) | 1.37 (1.18 to 1.59) | 1.36 (1.16 to 1.58) | 1.14 (0.93 to 1.39) |
| Duration on ART at AC entry (years) | ||||||
| 0 to 2 | 1.0 | 1.0 | 1.0 | 1.0 | 1.0 | 1.0 |
| 3 to 4 | 1.26 (0.96 to 1.65) | 1.25 (0.95 to 1.65) | 1.23 (0.89 to 1.70) | 0.95 (0.58 to 1.54) | 1.02 (0.62 to 1.66) | 0.94 (0.52 to 1.70) |
| ≥5 | 1.18 (0.92 to 1.51) | 1.27 (0.98 to 1.64) | 1.25 (0.92 to 1.70) | 1.25 (0.81 to 1.95) | 1.34 (0.84 to 2.11) | 1.51 (0.88 to 2.60) |
| CD4 count at AC entry (cells/µL) | ||||||
| <500 | 1.0 | – | 1.0 | 1.0 | – | 1.0 |
| ≥500 | 0.69 (0.55 to 0.85) | – | 0.67 (0.54 to 0.84) | 0.79 (0.54 to 1.15) | – | 0.75 (0.50 to 1.11) |
Model 1: univariable analysis; model 2: multivariable analysis including sex, age, year of AC entry and duration on ART at AC entry; model 3: model 2 including CD4 count at AC entry. For each outcome, only patients with a viral load on file were included in the model.